Searchable abstracts of presentations at key conferences in endocrinology

ea0022p734 | Steroid metabolism & action | ECE2010

Muscle fiber conduction slowing and decreased levels of circulating muscle proteins after short-term dexamethasone administration in healthy subjects

Lanfranco Fabio , Minetto Marco Alessandro , Botter Alberto , Baldi Matteo Domenico , Motta Giovanna , Ghigo Ezio , Arvat Emanuela

Context: Glucocorticoids are known to decrease protein synthesis and impair membrane excitability of muscle fibres. However, their short-term effects on muscle structure and function of healthy subjects remain poorly understood.Objective: To investigate whether steroid administration could decrease the circulating levels of muscle proteins and modify myoelectric indexes of sarcolemmal excitability and fatigability.Design: Single-bl...